Importance

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Abstract

Provided are: a biological reaction device that reduces stress and damage visited on microorganisms, etc., in a biological reaction, and enables a biological reaction in which microorganisms, etc., are used to be efficiently and economically performed; and a biological reaction method in which the biological reaction device is used. In order to reduce the stress and damage visited on microorganisms, etc., the amount per minute of a biological culture solution that is extracted from a culture tank and then returned to the culture tank after being admixed with micro-nano-bubbles is set as at least 1% to less than 48% of the biological culture solution accommodated in the culture tank, and the reduction in the dissolved oxygen concentration associated therewith is compensated for by setting the oxygen partial pressure of a gas phase in the upper part of the biological culture solution in the culture tank as at least 0.23 atm to less than 0.6 atm and/or setting the pressure of the gas phase in the upper part of the biological culture solution in the culture tank to at least 1.1 atm to less than 3.0 atm.

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First Claim