System and method for solution phase gap peptide synthesis
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United States of America Patent
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Mar 16, 2021
Grant Date -
Oct 31, 2019
app pub date -
Dec 21, 2016
filing date -
Dec 21, 2015
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Abstract
Disclosed is a system and method for Fmoc/tBu solution-phase peptide synthesis including the development of a new benzyl-type GAP protecting group, and related uses thereto. This novel GAP protecting group is utilized in place of a polymer support, facilitating C to N Fmoc peptide synthesis without chromatography, recrystallization, or polymer supports. The GAP group can be added and removed in high yield.
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