Method for joint arterial input function and tracer kinetic parameter estimation in accelerated DCE-MRI using a model consistency constraint

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United States of America Patent

PATENT NO 11982726
APP PUB NO 20190317171A1
SERIAL NO

16384795

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Tracer kinetic models are utilized as temporal constraints for highly under-sampled reconstruction of DCE-MRI data. In one embodiment, a method for improving dynamic contrast enhanced imaging. The method includes steps of administering a magnetic resonance contrast agent to a subject and then collecting magnetic resonance contrast agent from the subject. A tracer kinetic model (i.e. eTofts or Patlak) is selected to be applied to the magnetic resonance imaging data. The tracer kinetic model is applied to the magnetic resonance imaging data. Tracer kinetic maps and dynamic images are simultaneously reconstructed and a consistency constraint is applied. The proposed method allows for easy use of different tracer kinetic models in the formulation and estimation of patient-specific arterial input functions jointly with tracer kinetic maps.

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Patent OwnerAddress
UNIVERSITY OF SOUTHERN CALIFORNIA1150 SOUTH OLIVE STREET SUITE 2300 LOS ANGELES CA 90015

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Bliesener, Yannick Los Angeles, US 3 5
Guo, Yi San Francisco, US 236 1263
Lebel, Robert Marc Calgary, CA 19 74
Lingala, Sajan Goud Los Angeles, US 4 20
Nayak, Krishna S Long Beach, US 19 343
Zhu, Yinghua Lexington, US 8 23

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