Fibronectin based scaffold domain proteins that bind to myostatin

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United States of America Patent

PATENT NO 11813315
APP PUB NO 20190307855A1
SERIAL NO

16276156

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Abstract

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The present invention relates to fibronectin-based scaffold domain proteins that bind to myostatin. The invention also relates to the use of these proteins in therapeutic applications to treat muscular dystrophy, cachexia, sarcopenia, osteoarthritis, osteoporosis, diabetes, obesity, COPD, chronic kidney disease, heart failure, myocardial infarction, and fibrosis. The invention further relates to cells comprising such proteins, polynucleotides encoding such proteins or fragments thereof, and to vectors comprising the polynucleotides encoding the proteins.

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Patent Owner(s)

Patent OwnerAddress
BRISTOL-MYERS SQUIBB COMPANY345 PARK AVENUE NEW YORK N Y 10154

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Cload, Sharon Cambridge, US 13 297
Corbett, Martin J Mount Holly, US 23 269
Engle, Linda Framingham, US 17 341
Kozhich, Alexander T Princeton, US 16 206
Krystek,, Jr Stanley Richard Ringoes, US 11 66
Lipovsek, Dasa Cambridge, US 81 1800
Madireddi, Malavi West Windsor, US 10 169
Rakestraw, Ginger Chao Somerville, US 14 276
Ramamurthy, Vidhyashankar Bangalore, IN 6 59
Swain, Joanna Concord, US 12 169
Wei, Hui Princeton Junction, US 36 155
Yamniuk, Aaron P Lawrenceville, US 35 218
Zhao, Wenjun Montgomery, US 32 230

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