Method of processing dried samples using digital microfluidic device
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United States of America Patent
Stats
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May 11, 2021
Grant Date -
Jul 11, 2019
app pub date -
Mar 18, 2019
filing date -
May 5, 2010
priority date (Note) -
In Force
status (Latency Note)
Importance
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US Family Size
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Non-US Coverage
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Abstract
Methods are provided for the preparation of a sample using a digital microfluidic platform and the optional subsequent mass analysis of an extracted analyte. A sample is dried, optionally on a solid phase support, and contacted with digital microfluidic array. An analyte present within the dried sample is extracted into an extraction solvent by electrically addressing the digital microfluidic array to transport a droplet of extraction solvent to the dried sample spot. The extracted sample may be dried and subsequently processed on the digital micro fluidic array for derivatization. The digital microfluidic device may further include an integrated microfluidic channel having an output aperture, and the method may further include contacting a droplet containing extracted analyte with the microfluidic channel and applying a suitable electric field for generating nano-electrospray, thereby enabling the device to be directly interacted with a mass analysis device.
First Claim
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Family
| Country | kind | publication No. | Filing Date |
|---|---|---|---|
| CA | C | CA2798123 | Apr 15, 2011 |
| WO | A1 | WO2011137533 | Apr 15, 2011 |
| US | B2 | US10232374 | Apr 15, 2011 |
| EP | B1 | EP2567213 | Apr 15, 2011 |
International Classification(s)
- 2019 Application Filing Year
- H01J Class
- 2606 Applications Filed
- 1833 Patents Issued To-Date
- 70.34 % Issued To-Date
Cited Art Landscape
Patent Citation Ranking
- 0 Citation Count
- H01J Class
- 0 % this patent is cited more than
- 4 Age
Maintenance Fees
| Fee | Large entity fee | small entity fee | micro entity fee | due date |
|---|---|---|---|---|
| 7.5 Year Payment | $3600.00 | $1800.00 | $900.00 | Nov 11, 2028 |
| 11.5 Year Payment | $7400.00 | $3700.00 | $1850.00 | Nov 11, 2032 |
