Pyrazole derivative as ALK5 inhibitor and uses thereof
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United States of America Patent
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Mar 23, 2021
Grant Date -
Jun 27, 2019
app pub date -
Jun 30, 2017
filing date -
Jun 30, 2016
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Abstract
The present disclosure relates to a novel substituted pyrazole derivative having an effect of inhibiting serine/threonine kinase activity targeting receptor ALK5 of TGF-β, and a pharmaceutical composition including the compound of the present disclosure as an active ingredient may be useful in preventing and/or treating cancers, autoimmune diseases, fibrotic diseases, inflammatory diseases, neurodegenerative diseases, infectious diseases, pulmonary diseases, cardiovascular diseases or metabolic diseases, or other diseases associated with a decrease in TGF family signaling activity.
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