METHODS OF TREATING DRY EYE DISEASE USING TNF ALPHA ANTAGONISTS

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United States of America Patent

APP PUB NO 20190177407A1
SERIAL NO

16311001

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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The disclosure is directed to novel predictive methods and personalized therapies for treating dry eye disease (DED). Specifically, this disclosure relates to methods of treating a patient having DED by selectively administering a TNFα antagonist, e.g., a TNFα antibody, such as LME636, to the patient on the basis of that patient being genetically predisposed to have a favorable response to treatment with the TNFα antagonist. Also disclosed herein are transmittable forms of information, diagnostic methods, and kits useful in predicting the likelihood that a patient having DED will respond to treatment with a TNFα antagonist, e.g., a TNFα antibody, such as LME636.

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Patent OwnerAddress
NOVARTIS AGSCHWARZWALDALLEE 215 BASEL 4058

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
He, Yunsheng Waltham, US 13 49
Leisner, Christian Thalwil, CH 3 0
Wald, Michael Acton, US 6 48
Weissberber, Georges Marckolsheim, FR 1 0

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