Isolated phosphotriesterase polypeptides, polynucleotides encoding same and uses thereof in treating or preventing organophosphate exposure associated damage

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United States of America Patent

PATENT NO 10688330
APP PUB NO 20190083836A1
SERIAL NO

15535050

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Abstract

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A genetically modified polypeptide is disclosed which comprises an amino acid sequence of phosphotriesterase (PTE) having at least twice the catalytic efficiency for a V-type nerve agent as a polypeptide which consists of the sequence as set forth in SEQ ID NO: 1, when assayed under identical conditions.

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Patent Owner(s)

Patent OwnerAddress
YEDA RESEARCH AND DEVELOPMENT CO LTDWEIZMAN INSTITUTE OF SCIENCE P O BOX 95 REHOVOT 7610002

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Aggarwal, Nidhi Rehovot, IL 13 179
Ashani, Yaacov Rehovot, IL 4 7
Baker, David Seattle, US 251 2153
Cherny, Izhack Rehovot, IL 3 58
Fleishman, Sarel Rehovot, IL 14 9
Goldenzweig, Adi Rehovot, IL 5 0
Goldsmith, Moshe Rehovot, IL 4 12
Greisen, Per Jr Seattle, US 1 0
Khare, Sagar D Seattle, US 2 0
Leader, Haim Rehovot, IL 4 7
Oberdorfer, Gustav Seattle, US 3 0
Tawfik, Dan S Jerusalem, IL 18 117

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