Compound for enhancing the coupling degree of complex TRPV4-KCa2.3 and anti-hypertension applications thereof

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United States of America Patent

PATENT NO 10336712
APP PUB NO 20190077769A1
SERIAL NO

15773553

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Abstract

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The applicant provides a compound for enhancing the space coupling degree of an endothelial cell ion channel complex TRPV4-KCa2.3 and anti-hypertension applications thereof. By finding the structural domains of the interacting sites of the endothelial cell ion channel complex TRPV4-KCa2.3, a compound with specificity which can act at the two interacting sites is prepared in the present invention. It is found that the compound can enhance the space coupling degree of the TRPV4-KCa2.3 complex and has great significance for the research and development of anti-hypertension drugs.

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Patent Owner(s)

Patent OwnerAddress
JIANGNAN UNIVERSITY214000 7TH FLOOR SOUTH BUILDING NO 898 TONGSHA ROAD WUXI JIANGSU WUXI CITY JIANGSU PROVINCE 214000

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Cai, Yanfei Wuxi, CN 7 65
Chen, Zhen Wuxi, CN 228 1215
He, Dongxu Wuxi, CN 1 0
Ma, Xin Wuxi, CN 84 694
Tang, Chunlei Wuxi, CN 3 0
Zhang, Peng Wuxi, CN 846 8792

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