Importance

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Abstract

Provided are pharmaceutical composition particles which are capable of achieving both of masking of an unpalatable taste and improvement in dissolution properties; an orally disintegrating tablet including the pharmaceutical composition particles; and a method for manufacturing the pharmaceutical composition particles. Each of the pharmaceutical composition particles includes: a drug-containing core particle; an intermediate layer containing a gelling swelling substance and coating an outside of the core particle; and an outermost layer containing a water-insoluble substance and coating an outside of the intermediate layer. In addition, the method for manufacturing the pharmaceutical composition particles includes: a pulverization step of pulverizing the gelling swelling substance so as to have an average particle diameter of 15 μm or less; a suspension step of obtaining a suspension by suspending the gelling swelling substance pulverized at the pulverization step in an organic solvent; an intermediate layer formation step of forming an intermediate layer on an outside of a core particle by spraying the suspension obtained at the suspension step onto the core particle containing a drug; and an outer layer formation step of forming an outer layer by coating an outside of the intermediate layer with a water-insoluble substance.

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First Claim