Compositions and Methods for Genetically Modifying Myosin Phosphatase Target Subunit (Mypt1) Gene for Lowering Blood Pressure
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United States of America Patent
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Feb 14, 2019
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Mar 23, 2017
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Mar 23, 2016
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The present invention provides a method of lowering blood pressure in a subject, comprising genetically modifying a myosin phosphatase target subunit (Mypt1) gene in a vascular smooth muscle cell of the subject, whereby the genetic modification of Mypt1 results in a deletion or inactivation of exon 24. The invention further provides vectors, host cells, and compositions useful for carrying out the methods of the invention.
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