Expression and folding in the manufacturing process of CD-RAP by using a CD-RAP precursor protein

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United States of America Patent

PATENT NO 10660852
APP PUB NO 20190046442A1
SERIAL NO

15760321

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Abstract

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The present invention relates to a CD-RAP precursor protein comprising a pre-sequence and CD-RAP, and its use in manufacturing of native CD-RAP. The present invention further relates to a composition comprising CD-RAP and at least one positively charged amino acid and a buffer, pharmaceuticals comprising said composition, their use in methods of treating and/or preventing cartilage disease or injury in patients suffering from aggrecan degradation, and/or increased influx of water into the cartilage, and/or decreased CD-RAP expression, as well as methods of producing said composition and methods of storing CD-RAP in said composition. The present invention further relates to a composition comprising liposomes comprising encapsulated CD-RAP or a variant thereof, its use in methods of treating joint disease or injury, and methods of producing such liposomal composition as well as storing CD-RAP therein.

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Patent Owner(s)

Patent OwnerAddress
BIONET PHARMA GMBH80331 MÜNCHEN

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Bartnik, Eckart Frankfurt am Main, DE 21 358
Habermann, Paul Frankfurt am Main, DE 46 702
Janocha, Bernd Frankfurt am Main, DE 9 4
Jeske, Volker Frankfurt am Main, DE 3 0
Saas, Joachim Frankfurt am Main, DE 4 1
Schoettle, Isabell Frankfurt am Main, DE 10 114
Stillger, Ursula Frankfurt am Main, DE 1 0
Stommes, Judith Frankfurt am Main, DE 2 0

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