POLYPEPTIDES, ANTIBODY VARIABLE DOMAINS & ANTAGONISTS

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United States of America Patent

APP PUB NO 20190040148A1
SERIAL NO

16047197

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Abstract

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The invention relates to anti-TNFR1 polypeptides and antibody single variable domains (dAbs) that are resistant to degradation by a protease, as well as antagonists comprising these. The polypeptides, dAbs and antagonists are useful for as therapeutics and/or prophylactics that are likely to encounter proteases when administered to a patient, for example for pulmonary administration, oral administration, delivery to the lung and delivery to the GI tract of a patient, as well as for treating inflammatory disease, such as arthritis or COPD.

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Patent Owner(s)

Patent OwnerAddress
DOMANTIS LIMITEDBRENTFORD MIDDLESEX TW8 9GS

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Enever, Carolyn Cambrige, GB 26 41
JESPERS, Laurent Cambridge, GB 27 223
Pupecka-Swider, Malgorzata Cambridgeshire, GB 10 0
Tomlinson, Ian Cambridge, GB 46 849

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