HAPLOTYPING OF HLA LOCI WITH ULTRA-DEEP SHOTGUN SEQUENCING

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United States of America Patent

APP PUB NO 20190002979A1
SERIAL NO

15926781

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Abstract

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Methods are provided to determine the entire genomic region of a particular HLA locus including both intron and exons. The resultant consensus sequences provides linkage information between different exons, and produces the unique sequence from each of the two genes from the individual sample being typed. The sequence information in intron regions along with the exon sequences provides an accurate HLA haplotype.

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Patent Owner(s)

Patent OwnerAddress
THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY1705 EL CAMINO REAL PALO ALTO CA 94306

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Davis, Mark M Atherton, US 46 616
Davis, Ronald W Stanford, US 96 3007
Krishnakumar, Sujatha Palo Alto, US 7 108
Mindrinos, Michael N Palo Alto, US 9 214
Wang, Chunlin Palo Alto, US 26 166

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