METHOD OF MANUFACTURING BISPECIFIC ANTIBODIES, BISPECIFIC ANTIBODIES AND THERAPEUTIC USE OF SUCH ANTIBODIES

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United States of America Patent

APP PUB NO 20190002589A1
SERIAL NO

16005088

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Abstract

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The invention relates to bivalent bispecific monoclonal antibodies (bbmAb) or variants thereof, and methods of manufacturing such antibodies by co-expressing modified Fc-mutated derivatives of two different monoclonal antibodies in mammalian cell lines.

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Patent Owner(s)

Patent OwnerAddress
NOVARTIS PHARMA AGLICHTSTRASSE 35 BASEL 4056

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
BARDROFF, Michael Otto Loerrach, DE 10 26
BUCH, Tina Efringen-Kirchen, DE 3 9
GRAF, Christian München, DE 37 545
HEITMANN, Daniel Zürich, CH 6 23
JOSTOCK, Thomas Neuenburg am Rhein, DE 23 124
KNOPF, Hans-Peter Schallstadt, DE 21 49
KOEHLER, Rolf Basel, CH 3 9
KOVARIK, Jiri Zürich, CH 10 49
OLIVER, Stephen John Basel, CH 6 10
PATEL, Dhavalkumar Basel, CH 29 159
WOISETSCHLAEGER, Maximilian Oberwil, CH 17 60

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