MIMICRY OF NEUROINFLAMMATORY MICROENVIRONMENTS AND METHODS OF USE AND MANUFACTURING THEREOF
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United States of America Patent
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Dec 13, 2018
app pub date -
Aug 7, 2017
filing date -
Aug 7, 2017
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Abstract
A method for simulating the neuroinflammatory response in brains comprising the steps of providing a microfluidic device for regulating microgliosis comprising a base, a central chamber located on the base, a size-exclusive barrier surrounding the central chamber, an annular chamber outside the barrier, a plurality of selective cellular migration channels connecting the annular chamber to the central chamber, a central reservoir in fluid communication with the central chamber and side reservoirs in fluid communication with the annular chamber; providing a camera to record the microfluidic device and cells, culturing a plurality of microglial cells within the central or annular chamber, culturing a plurality of a second cell type within the annular or central chamber, adding a chemoattractant to the central chamber and recording the microfluidic device for a period of time to record the morphogenesis of activated cells in the annular chamber and migration across the barrier.
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