INACTIVATION OF PROTEASES

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United States of America Patent

APP PUB NO 20180346950A1
SERIAL NO

16059584

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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The invention relates to a process for inactivating proteases by repeatedly changing the pH in the cell culture supernatant at the start of the process for the purification of biopharmaceuticals. The pH is adjusted first to 3-5, and then to 7-9.

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Patent Owner(s)

Patent OwnerAddress
BOEHRINGER INGELHEIM INTERNATIONAL GMBHGERMANY INGELHEIM AM RHEIN RHINELAND-PALATINATE

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
AMBROSIUS, Dorothee Laupheim, DE 19 507
DOBBERTHIEN, Philine Warthausen, DE 5 17
ECKERMANN, Christian Biberach an der Riss, DE 5 105
JACOBI, Alexander Laupheim, DE 4 12
NOTHELFER, Franz Biberach an der Riss, DE 4 43

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