EPITOPE OF OPTIMIZED HUMANIZED MONOCLONAL ANTIBODIES AGAINST ACTIVATED PROTEIN C AND USES THEREOF
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United States of America Patent
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Nov 15, 2018
app pub date -
Nov 15, 2016
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Nov 15, 2016
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Abstract
Provided are optimized humanized antibodies that selectively bind to and inhibit activated protein C without binding to or inhibiting unactivated protein C. In particular, the antibodies bind to particular epitopes outside the catalytic triad of the active site of human activated protein C. Methods of treatment employing these antibodies are described herein.
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