Ferroportin inhibitors
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United States of America Patent
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Jul 30, 2019
Grant Date -
Nov 8, 2018
app pub date -
Oct 21, 2016
filing date -
Oct 23, 2015
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Abstract
The invention relates to novel compounds of the general formula (A-I), with Het-2 being an optionally substituted bicyclic heteroaryl of the formula (AA) pharmaceutical compositions comprising them and the use thereof as medicaments, in particular for the use as ferroportin inhibitors, more particularly for the use in the prophylaxis and/or treatment of diseases caused by a lack of hepcidin or iron metabolism disorders, such as particularly iron overload states such as in particular thalassemia and hemochromatosis.
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