PHARMACEUTICAL FORMULATION AND METHOD OF PREPARING THE SAME
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United States of America Patent
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Oct 18, 2018
app pub date -
Apr 12, 2017
filing date -
Apr 12, 2017
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A pharmaceutical formulation including a chelator-somatostatin receptor ligand and a transchelator is provided. The chelator-somatostatin receptor ligand is conjugated with a metal source or a radionuclide source, whereas the transchelator is capable of capturing free metal source or radionuclide source that is not conjugated to the chelator-somatostatin receptor ligand. By using such pharmaceutical formulation, the preparation of radiolabeled somatostatin analogues could be made more efficient, and is feasible for imaging of SSTR pathway-activated systems in cancers and neurological diseases.
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