USE OF PEPTIDE HYDROGEL SCAFFOLDS FOR THREE-DIMENSIONAL THROUGHPUT DRUG DISCOVERY

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United States of America Patent

APP PUB NO 20180267019A1
SERIAL NO

15762228

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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An assay mixture includes a hydrogel of a shear-thinning β-hairpin peptide, a plurality of cells, and one or more predetermined compounds being investigated for ability to affect the growth, viability, reproduction characteristics, or activity of the cells. A high throughput screening device includes a plurality of sample wells adapted for high throughput screening, wherein each well contains the assay mixture. A method of using the high throughput screening device includes a) depositing in each of the wells a β-hairpin hydrogel including the cells; depositing in at least some of the wells one or more of the compounds, either along with the β-hairpin hydrogel or separately; and c) measuring the growth, viability, reproduction characteristics, or activity of the cells in each of the plurality of wells.

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Patent Owner(s)

Patent OwnerAddress
UNIVERSITY OF DELAWARENEWARK DE 19716

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
LANGHANS, Sigrid A Chadds Ford, US 1 0
NAPPER, Andrew D Dublin, US 14 60
POCHAN, Darrin J Landenberg, US 9 88
WORTHINGTON, Peter Haddon Heights, US 14 158

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