Multi-functionalized polysaccharide compounds and use thereof for targeting the cation-independent mannose 6-phosphate receptor

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United States of America Patent

PATENT NO 10894803
APP PUB NO 20180265534A1
SERIAL NO

15759879

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Abstract

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The subject matter of the present invention is a compound characterized in that it has the general formula (I): in which P1, X, n, A, L and L1 are as defined in Claim 1. The present invention also relates to a process for preparing said compounds (I) and to the use thereof for targeting the cation-independent mannose 6-phosphate receptor (CI-M6PR). The subject matter of the invention is also a conjugate of formula (III): in which P1, X, n, A, L and L′1 are as defined in Claim 6, and the use thereof: —in a method for therapeutic treatment of the human or animal body, in particular chosen from enzyme replacement therapy, photodynamic therapy or cancer treatment, and/or—in a method of diagnosis, in particular of diseases or of ailments associated with an increase or with a decrease in CI-M6PR expression.

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Patent Owner(s)

Patent OwnerAddress
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE75007 PARIS
UNIVERSITÉ DE MONTPELLIER34090 MONTPELLIER
NANOMEDSYN15 AVENUE CHARLES FLAHAULT FACULTÉ DE PHARMACIE BAT E 2ÈME ÉTAGE MONTPELLIER CEDEX 5 34093

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Basile, Ilaria Saint Gely du Fesc, FR 2 19
Bouffard, Elise Mignaloux Beauvoir, FR 1 2
Da, Silva Afitz Montpellier, FR 1 2
Durand, Jean-Olivier Palavas les Plots, FR 6 11
El, Cheikh Khaled Montpellier, FR 2 19
Maynadier, Marie Ceyras, FR 4 5
Morere, Alain Saint Gely du Fesc, FR 7 26

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