Process for making M1 receptor positive allosteric modulators
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United States of America Patent
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Jun 4, 2019
Grant Date -
Sep 20, 2018
app pub date -
Sep 26, 2016
filing date -
Sep 30, 2015
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Abstract
This invention provides novel processes for the preparation of compounds such as 3-[(1S,2S)-2-hydroxycyclohexyl]-6-[(6-methylpyridin-3-yl)methyl]benzo[h]-quinazolin-4(3H)-one, salts and derivatives thereof. The compounds synthesized by the processes of the invention are useful for treating Alzheimer's disease and other diseases (e.g., cognitive impairment, schizophrenia, pain disorders, and sleep disorders) mediated by the muscarinic M1 receptor.
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