ANTIBODIES TO ENDOPLASMIN AND THEIR USE

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United States of America Patent

APP PUB NO 20180230205A1
SERIAL NO

15870532

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Abstract

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Isolated monoclonal antibodies are disclosed herein that specifically bind endoplasmin In some embodiments these antibodies are fully human. Recombinant nucleic acids encoding these antibodies, expression vectors including these nucleic acids, and host cells transformed with these expression vectors are also disclosed herein. In several embodiments the disclosed antibodies are of use for detecting and/or treating tumors that express endoplasmin, such as melanoma, breast cancer, head and neck squamous cell carcinoma, renal cancer, lung cancer, glioma, bladder cancer, ovarian cancer or pancreatic cancer. In one example, the tumor is a melanoma.

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Patent Owner(s)

Patent OwnerAddress
UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION130 THACKERAY AVE 1ST FLOOR GARDNER STEEL CONFERENCE CENTER PITTSBURGH PA 15260

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Conrads, Thomas P Reston, US 9 45
Favoino, Elvira Bari, IT 7 25
Ferrone, Soldano Boston, US 43 164
Hood, Brian L Reston, US 6 23
Wang, Xinhui Boston, US 117 1849

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