Oligodendroglioma drive genes

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United States of America Patent

PATENT NO 10619217
APP PUB NO 20180195132A1
SERIAL NO

15834886

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Oligodendrogliomas are the second most common malignant brain tumor in adults. These tumors often contain a chromosomal abnormality involving a pericentromeric fusion of chromosomes 1 and 19, resulting in losses of the entire short arm of the former and the long arm of the latter. To identify the molecular genetic basis for this alteration, we performed exomic sequencing of seven anaplastic oligodendrogliomas with chromosome 1p and 19q losses. Among other changes, we found that that CIC (homolog of the Drosophila gene capicua) on chromosome 19q was somatically mutated in six of the seven cases and that FUBP1 (far upstream element (FUSE) binding protein) on chromosome 1p was somatically mutated in two of the seven cases. Examination of 27 additional oligodendrogliomas revealed 12 and 3 more tumors with mutations of CIC and FUBP1, respectively, 58% of which were predicted to result in truncations of the encoded proteins. These results suggest a critical role for these genes in the biology and pathology of oligodendrocytes.

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Patent Owner(s)

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DUKE UNIVERSITYOFFICE OF TECHNOLOGY TRANSFER DURHAM NC 27706

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Agrawal, Nishant Baltimore, US 14 37
Bettegowda, Chetan Baltimore, US 16 38
Bigner, Darell Mebane, US 46 351
Kinzler, Kenneth W Baltimore, US 296 5437
McLendon, Roger Durham, US 2 3
Papadopoulos, Nickolas Towson, US 104 1312
Vogelstein, Bert Baltimore, US 338 7135
Yan, Hai Chapel Hill, US 85 1001

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