Automated delineation of nuclei for three dimensional (3-D) high content screening
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United States of America Patent
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Aug 4, 2020
Grant Date -
Mar 15, 2018
app pub date -
Apr 22, 2016
filing date -
Apr 23, 2015
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Abstract
In various embodiments, the invention teaches systems and methods for analyzing an image of cells, including an image obtained by confocal microscopy, and delineating cell nuclei in the image. In some embodiments, the systems and methods apply a three-dimensional (3-D) radial symmetry transform followed by adaptive post processing of symmetry images to arrive at a mask of seeds that can guide watershed-based segmentation.
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