Preparation method for aerolysin nanopore and application thereof
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United States of America Patent
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Sep 29, 2020
Grant Date -
Mar 8, 2018
app pub date -
Jan 8, 2016
filing date -
Jan 30, 2015
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Abstract
A preparation method for an aerolysin nanopore in this disclosure comprises the following steps: (1) pretreatment of an aerolysin; (2) preparation of a lipid bilayer membrane by pulling process; (3) forming of the aerolysin nanopore: the aerolysin nanopore is obtained at a current of 50±5 pA. The aerolysin nanopore prepared in the invention is structurally stable and has a high resolution with the whole internal cavity carried with a positive charge, can be used for detection without modification and is easily operated. Further, the aerolysin nanopore can be applied in DNA sequencing, DNA damage and Micro-RNA detection.
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