DNA-METHYLATION BASED METHOD FOR CLASSIFYING TUMOR SPECIES
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United States of America Patent
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Mar 8, 2018
app pub date -
Sep 15, 2016
filing date -
Mar 11, 2015
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Abstract
The present invention pertains to methods for classifying tumorous diseases based on their specific genomic DNA methylation profile. The invention provides a method that allows for a classification of a tumor sample obtained from a patient by analysing a multitude, preferably genome wide, collection of CpG positions by comparison to a classification rule derived from a set of methylation data acquired from pre-classified tumor species. The invention is in particular useful for classifying brain tumor samples since brain tumors are characterized by a large variety of distinct tumor species which have different prognostic values and require in the clinic a for each species developed treatment regime.
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