Use of excess carbodiimide for peptide synthesis at elevated temperatures

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United States of America Patent

PATENT NO 10858390
APP PUB NO 20180066013A1
SERIAL NO

15686719

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Abstract

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An improved method of coupling amino acids into peptides or peptidomimetics is disclosed in which the activation and coupling are carried out in the same vessel, in the presence of a carbodiimide in an amount greater than 1 equivalent as compared to the amino acid, in the presence of an activator additive, and at a temperature greater than 30° C.

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Patent Owner(s)

Patent OwnerAddress
CEM CORPORATION3100 SMITH FARM ROAD MATTHEWS NC 28106

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Collins, Jonathan M Charlotte, US 12 39
Singh, Sandeep K Matthews, US 8 27

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