HIGH PERFORMANCE LIQUID CHROMATOGRAPHY METHOD FOR ANALYSIS OF MN DIAGNOSTIC AND THERAPEUTIC LIGAND AND PRECURSOR

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United States of America Patent

SERIAL NO

15254118

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Abstract

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A high performance liquid chromatography method for analysis of a MN diagnostic and therapeutic ligand and precursors is revealed. Polarity of eluents used during elution is changed to remove impurities. First use a first eluent with a lower ratio of acetonitrile as a mobile phase to elute analytes. Then a second eluent in which a ratio of acetonitrile is increased into 97˜99% is used to elute the analytes for at least 20 minutes. Next use the first eluent to elute the analytes for at least 60 minutes. Thus no residual impurities are left in the column and the analytes remain in the column stably. Therefore a more accurate and reproductive result is obtained.

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Patent Owner(s)

Patent OwnerAddress
INSTITUTE OF NUCLEAR ENERGY RESEARCH ATOMIC ENERGY COUNCIL EXECUTIVE YUAN R O CNO 1000 WENHUA RD JIAAN VILLAGE LONGTAN DISTRICT TAOYUAN CITY 32546

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
CHANG, YU TAOYUAN COUNTY, TW 87 3445
HSU, CHENG-FANG TAOYUAN COUNTY, TW 28 36
LU, KUEI-LIN TAOYUAN COUNTY, TW 7 30
TSAI, JIA-DONG TAOYUAN COUNTY, TW 2 0

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