Vectors and methods for targeted integration in loci comprising constitutively expressed genes
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United States of America Patent
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Aug 18, 2020
Grant Date -
Mar 1, 2018
app pub date -
Nov 10, 2015
filing date -
Nov 10, 2014
priority date (Note) -
In Force
status (Latency Note)
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Abstract
The invention relates to a vector comprising: a 5′ nucleic acid that is homologous to a genomic sequence 5′ of a stop codon of a constitutively expressed gene; an exogenous nucleic acid; a 3′ nucleic acid that is homologous to a genomic sequence 3′ of the stop codon of the constitutively expressed gene; a translation interruption-reinitiation signal operably linked to the 5′ nucleic acid and the exogenous nucleic acid, wherein the translation interruption-reinitiation signal is capable of replacing the stop codon of the constitutively expressed gene.
First Claim
Other Claims data not available
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| Country | kind | publication No. | Filing Date |
|---|---|---|---|
| JP | A | JP2017534301 | Nov 10, 2015 |
| CA | A1 | CA2967060 | Nov 10, 2015 |
| AU | A1 | AU2015345979 | Nov 10, 2015 |
| WO | A1 | WO2016074016 | Nov 10, 2015 |
| EP | A1 | EP3218503 | Nov 10, 2015 |
International Classification(s)
- 2015 Application Filing Year
- C12N Class
- 6649 Applications Filed
- 4472 Patents Issued To-Date
- 67.26 % Issued To-Date
Cited Art Landscape
Patent Citation Ranking
- 0 Citation Count
- C12N Class
- 0 % this patent is cited more than
- 5 Age
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| 7.5 Year Payment | $3600.00 | $1800.00 | $900.00 | Feb 18, 2028 |
| 11.5 Year Payment | $7400.00 | $3700.00 | $1850.00 | Feb 18, 2032 |
