siRNA sequence-independent modification formats for reducing off-target phenotypic effects in RNAi, and stabilized forms thereof
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United States of America Patent
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Jun 25, 2019
Grant Date -
Mar 1, 2018
app pub date -
Sep 5, 2017
filing date -
Sep 19, 2007
priority date (Note) -
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status (Latency Note)
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Abstract
Modification formats having modified nucleotides are provided for siRNA. Short interfering RNA having modification formats and modified nucleotides provided herein reduce off-target effects in RNA interference of endogenous genes. Further modification formatted siRNAs are demonstrated to be stabilized to nuclease-rich environments. Unexpectedly, increasing or maintaining strand bias, while necessary to maintain potency for endogenous RNA interference, is not sufficient for reducing off-target effects in cell biology assays.
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International Classification(s)
- 2017 Application Filing Year
- C12N Class
- 8593 Applications Filed
- 4882 Patents Issued To-Date
- 56.82 % Issued To-Date
Cited Art Landscape
Patent Citation Ranking
- 1 Citation Count
- C12N Class
- 64.95 % this patent is cited more than
- 6 Age
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