MZB1, a novel B cell factor, and uses thereof
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United States of America Patent
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Nov 3, 2020
Grant Date -
Mar 1, 2018
app pub date -
Aug 29, 2017
filing date -
Mar 31, 2008
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Abstract
The marginal zone (MZ) and B1 subsets of B cells, which differ from conventional follicular (FO) B cells both developmentally and functionally, are involved in early responses to infectious pathogens and the production of self-reactive antibodies. A novel gene, mzb1, is expressed at high levels in MZ and B1 B cells but at low level, if at all, in FO B cells. MZB1 is involved in the regulation of proliferation, BCR-mediated signal transduction, and antibody production in B cells. Inhibitors, activators and enhancers of MZB1 expression or activity can be used as immune modulators for research and therapeutic purposes.
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