METHODS AND COMPOSITIONS FOR TREATMENT OF DERMAL AND EPIDERMAL WOUNDS
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United States of America Patent
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Issued Date -
Mar 1, 2018
app pub date -
Oct 31, 2017
filing date -
Jul 28, 2011
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Abstract
This disclosure relates to compositions and methods for the treatment of dermal and epidermal wounds. In particular, the disclosure relates to treating dermal and epidermal wounds based on application of a composition comprising an opioid receptor antagonist, a pharmaceutically acceptable carrier, and an enkephalinase. In some cases, the enkephalinase comprises aminopeptidase N (APN), neprilysin, dipeptidyl peptidase 3 (DPP3), carboxypeptidase A6 (CPA6), leucyl/cystinyl aminopeptidase (LNPEP), angiotensin-converting enzyme (ACE), endothelin-converting enzyme-2 (ECE-2), a peroxin (PEX), damage induced neuronal endopeptidase (DINE), Kell protein, or a combination thereof.
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