Method for studying V(D)J combinatory diversity

Number of patents in Portfolio can not be more than 2000

United States of America Patent

PATENT NO 11773442
APP PUB NO 20180051334A1
SERIAL NO

15804693

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Abstract

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The invention relates to a method for analyzing the diversity of the catalogue of T and/or B lymphocytes in an individual, based on the amplification, from a sample, of genomic DNA fragments by PCR multi-n-plexes, with n≥2, carried out with a combination of at least 3 primers defining at least 2 primer couples, each of which includes a primer specifically hybridizing upstream and/or in a given V or D gene and a primer specifically hybridizing downstream and/or in a given J gene, in order to obtain the amplification of at least two fragments characteristic of two distinct V-J or D-J rearrangements from each primer couple. The invention also relates to the applications of this method, in particular in the treatment follow-up or in the diagnosis and/or prognosis of certain diseases.

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Patent Owner(s)

Patent OwnerAddress
ADAPTIVE BIOTECHNOLOGIES CORPORATION1165 EASTLAKE AVENUE EAST SEATTLE WA 98102

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Pasqual, Nicolas Grenoble, FR 5 145
Weisbuch, Sebastien Villefontaine, FR 2 0

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