with an O-antigen having an extended carbohydrate chain and use thereof

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United States of America Patent

PATENT NO 10780154
APP PUB NO 20180050100A1
SERIAL NO

15532823

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Abstract

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The present invention discloses a Salmonella paratyphi A with an O-antigen having an extended carbohydrate chain and uses thereof. The method comprises the following steps: inactivating an cld gene encoding an enzyme controlling chain length of O-antigen of a Salmonella paratyphi A strain to obtain a Salmonella paratyphi A with deletion of cld gene; allowing overexpression of cldLT2 gene encoding an enzyme controlling chain length of O-antigen of Salmonella typhimurium in Salmonella paratyphi A deficient in the cld gene encoding an enzyme controlling chain length of O-antigen, so as to extend carbohydrate chain length of O-antigen. Both of the Salmonella paratyphi A O-polysaccharide-recombinant fusion protein conjugate vaccines rCTB45733-OPSSpty50973 and rEPA4573-OPSSpty50973 as prepared by using Salmonella paratyphi A with an O-antigen having an extended carbohydrate chain can induce mice to generate specific antibodies against Salmonella paratyphi A, and their antibody titers are significantly improved.

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Patent OwnerAddress
INSTITUTE OF BIOTECHNOLOGY ACADEMY OF MILITARY MEDICAL SCIENCES CHINABEIJING 100071

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Chang, Shaohong Beijing, CN 2 2
Feng, Erling Beijing, CN 4 2
Gong, Xin Beijing, CN 16 48
Liu, Bo Beijing, CN 672 3701
Pan, Chao Beijing, CN 23 44
Sun, Peng Beijing, CN 452 1010
Wang, Hengliang Beijing, CN 4 2
Wang, Tiantian Beijing, CN 11 5
Wu, Jun Beijing, CN 507 5138
Zhu, Li Beijing, CN 164 1000

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