Reprogramming progenitor compositions and methods of use therefore
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United States of America Patent
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Feb 16, 2021
Grant Date -
Feb 15, 2018
app pub date -
Feb 26, 2016
filing date -
Feb 27, 2015
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Abstract
The invention generally features compositions comprising induced pluripotent stem cell progenitors (also termed reprogramming progenitor cells) and methods of isolating such cells. The invention also provides compositions comprising induced pluripotent stem cells (iPSCs) derived from such progenitor cells. Induced pluripotent stem cell progenitors generate iPSCs at high efficiency. In particular embodiments the invention is predicated upon increased expression of an estrogen related receptor and changes in the oxidative and glycolytic pathways.
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