Two stage cellularization strategy for the fabrication of bioartificial hearts
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United States of America Patent
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Oct 6, 2020
Grant Date -
Feb 15, 2018
app pub date -
Oct 5, 2017
filing date -
May 2, 2014
priority date (Note) -
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Abstract
In some embodiments, the present disclosure pertains to a method of fabricating an artificial heart muscle (AHM) patch. In some embodiments, the method includes obtaining and/or isolating cells from a subject. In some embodiments, the cells are primary cardiac cells. In some embodiments, the method further includes forming a scaffold. In some embodiments, the method includes seeding the cells in the fibrin gel scaffold. In some embodiments, the method includes culturing the cells seeded in the fibrin gel scaffold under conditions appropriate for the formation of an artificial heart muscle (AHM) patch.
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