Modified cyclopentapeptides and uses thereof

Number of patents in Portfolio can not be more than 2000

United States of America Patent

PATENT NO 10919938
APP PUB NO 20180037608A1
SERIAL NO

15315290

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Abstract

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The present invention, among others, relates to a compound having a structure according to formula (I) or a pharmaceutically acceptable salt thereof, wherein Xaa1 are the iodo-substituted or methyl-substituted amino acids D- and L-Tyr, iodo-substituted or methyl- substituted D- and L-homotyrosine, iodo-substituted or methyl-substituted D- and L-Phe, iodo-substituted or methyl-substituted D- and L-p-OH-phenylglycine, and iodo-substituted or methyl-substituted D- or L-Trp, Xaa2 to Xaa4 are independently of each other, an optionally N-alkylated natural or unnatural amino acid, R is H or methyl, L is a linker moiety, Ar is a spacer comprising an aromatic moiety, and D comprises, preferably is i) a combination of an organic complexation agent and a radioactive or a detectable label; or ii) a radioactive or a detectable label, an organic complexation agent or an active substance, said active substance particularly being selected from cytotoxic agents, lipids, sugars, sugar conjugates, sugar derivatives, proteins and combinations thereof.

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Patent Owner(s)

Patent OwnerAddress
TECHNISCHE UNIVERSITAT MUNCHEN80333 MÜNCHEN

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Osl, Theresa Munich, DE 6 1
Poschenrieder, Andreas Munich, DE 1 1
Schottelius, Margret Munich, DE 8 6
Wester, Hans-Jürgen Immünster, DE 21 11
Willibald, Marina Weßling, DE 1 1

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