Sanitization Method for Affinity Chromatography Matrices
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United States of America Patent
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Feb 8, 2018
app pub date -
Feb 25, 2016
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Mar 3, 2015
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Abstract
The invention discloses a method for cleaning or sanitization of an affinity chromatography matrix, comprising the steps of: a) providing an affinity chromatography matrix having oxidation-tolerant proteinaceous ligands coupled to a support, b) contacting the matrix with a sanitization solution comprising at least one oxidant defined by formula I, R—O—O—H (I) wherein R is hydrogen or an acyl group R′—C(O)—, with R′ being a hydrogen or a methyl, ethyl or propyl group.
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