Capsid modified rAAV vectors and methods of use

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United States of America Patent

PATENT NO 10723768
APP PUB NO 20180036428A1
SERIAL NO

15680668

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Abstract

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Disclosed are tyrosine-modified rAAV vectors, as well as infectious virions, compositions, and pharmaceutical formulations that comprise them. Also disclosed are methods of preparing and methods for using the disclosed tyrosine-phosphorylated capsid protein mutant rAAV vectors in a variety of diagnostic and therapeutic applications including in vivo and ex vivo gene therapy, and large-scale production of rAAV vectors.

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Patent Owner(s)

Patent OwnerAddress
UNIVERSITY OF FLORIDA RESEARCH FOUNDATION INCORPORATED223 GRINTER HALL GAINESVILLE FL 32611

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Agbandje-McKenna, Mavis Gainesville, US 50 1290
Govindasamy, Lakshmanan Gainesville, US 14 485
Srivastava, Arun Gainesville, US 52 1327
Zhong, Li Gainesville, US 49 739
Zolotukhin, Sergei Gainesville, US 53 1558

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