ELIMINATION OF PROLIFERATING CELLS FROM STEM CELL-DERIVED GRAFTS
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Jun 30, 2017
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Jul 1, 2016
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Provided herein are methods and compositions for a suicide gene approach comprising an expression vector comprising a cell cycle-dependent promoter driving the expression of a suicide gene. Also provided herein are methods to render proliferative cells sensitive to a prodrug after transplantation but avoids expression of the suicide gene in post-mitotic cells, such as neurons.
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