Modified AXL peptides and their use in inhibition of AXL signaling in anti-metastatic therapy

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United States of America Patent

PATENT NO 11136563
APP PUB NO 20180030422A1
SERIAL NO

15783850

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Abstract

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Compositions and methods are provided for alleviating cancer in a mammal by administering a therapeutic dose of a pharmaceutical composition that inhibits activity of AXL, MER or Tyro3 protein activity, for example by competitive or non-competitive inhibition of the binding interaction between AXL, MER or Tyro3 and its ligand GAS6.

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Patent Owner(s)

Patent OwnerAddress
RUGA CORPORATION550 HAMILTON AVE SUITE 220 PALO ALTO CA 94301

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Cochran, Jennifer R Stanford, US 74 431
Fuh, Katherine Cynthia St. Louis, US 2 0
Giaccia, Amato J Stanford, US 30 262
Hershenson, Susan Palo Alto, US 9 319
Jones, Douglas Newton, US 61 1153
Kariolis, Mihalis Stanford, US 33 210
Miao, Yu Sunnyvale, US 29 142
Rankin, Erinn Bruno Redwood City, US 11 124

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