METHOD OF ALTERING EXPRESSION OF ALTERNATIVE VIRAL GLYCOPROTEIN COMPLEXES
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Feb 16, 2016
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Feb 16, 2015
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A method of preparing a vaccine for immunization against a herpes virus comprising the steps of one of deleting, substituting, or modifying a UL148 gene and interfering with or modifying an expression of the UL148 gene. Wherefore, it is an object of the present invention to overcome the above mentioned shortcomings and drawbacks associated with the prior art The inventors observed that less extensively passaged HCMV strains that retain expression of gH/gL/UL128-131 can efficiently infect epithelial and endothelial cells.
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