ICOS BINDING PROTEINS

Number of patents in Portfolio can not be more than 2000

United States of America Patent

APP PUB NO 20180030136A1
SERIAL NO

15546369

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ATTORNEY / AGENT: (SPONSORED)

Importance

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Abstract

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The present invention relates to an ICOS binding protein or antigen binding portion thereof that is an agonist to human ICOS and does not induce complement, ADCC, or CDC when placed in contact with a T cell in vivo and methods of treating cancer, infectious disease and/or sepsis with said ICOS binding protein or antigen binding portion thereof. Further the ICOS binding proteins or antigen binding portions thereof of the present invention are capable of activating a T cell when placed in contact with said T cell; stimulating T cell proliferation when placed in contact with said T cell and/or inducing cytokine production when placed in contact with said T cell. The present invention relates to ICOS binding proteins or antigen binding portions thereof comprising one or more of: SEQ ID NO:1; SEQ ID NO:2; SEQ ID NO:3; SEQ ID NO:4; SEQ ID NO:5; and/or SEQ ID NO:6.

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Patent Owner(s)

Patent OwnerAddress
GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED980 GREAT WEST ROAD BRENTFORD MIDDLESEX TW8 9GS

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
LIU, Yao-Bin Collegeville, US 9 58
Mayes, Patrick Collegeville, US 32 134
OLIVE, Daniel Marseille, FR 52 375
Parmar, Radha Shah Stevenage, Hertfordshire, GB 23 161

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