Composition and method for affecting the binding of antigen-binding polypeptides to antigens
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United States of America Patent
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Aug 4, 2020
Grant Date -
Feb 1, 2018
app pub date -
Jul 14, 2017
filing date -
Jul 29, 2016
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Abstract
The present invention provides a composition comprising i) a polypeptide comprising calmodulin and two immunoglobulin superfamily domains, wherein said two immunoglobulin superfamily domains are linked via said calmodulin; ii) a calmodulin binding molecule; iii) ions binding to the Ca2+ binding site of calmodulin; wherein the binding of said calmodulin-binding molecule and of said ions to said Ca2+ binding site of calmodulin affects the binding of said polypeptide to an antigen to be bound by said polypeptide. The calmodulin may be a permutated calmodulin. A method for affecting the binding of a polypeptide for an antigen using said composition is also disclosed.
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