MYC G-quadruplex stabilizing small molecules and their use
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United States of America Patent
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Feb 5, 2019
Grant Date -
Feb 1, 2018
app pub date -
Jan 5, 2016
filing date -
Jan 5, 2015
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Abstract
Methods for treating a tumor, such as a benign or malignant tumor, are disclosed herein. The methods include administering a therapeutically effective amount of a small molecule that selectively binds to and stabilizes G-quadruplex DNA in the promoter of the c-MYC gene to the subject. The methods are also of use to decrease the size and/or number of metastases. Compounds for use in the disclosed methods are also provided.
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