ANTIBODY-DRUG CONJUGATES FOR REDUCING THE LATENT HIV RESERVOIR
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Feb 16, 2016
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Feb 16, 2015
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Disclosed herein are antibody-drug conjugates having the general formula A-L-D, wherein A represents a neutralizing antibody specific for human immunodeficiency virus (HIV), L represents a linker, and D represents a cytotoxic moiety, pharmaceutical compositions comprising the antibody-drug conjugates, and methods of treating HIV with the antibody-drug conjugates after activation of latent reservoir cells.
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