THERMAL INACTIVATION OF ROTAVIRUS
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United States of America Patent
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Issued Date -
Feb 1, 2018
app pub date -
Oct 4, 2017
filing date -
Sep 4, 2007
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Abstract
Methods of thermally inactivating a rotavirus are provided according to the present invention which include exposing the rotavirus to a temperature in the range of about 50° C.-80° C., inclusive, for an incubation time sufficient to render the rotavirus incapable of replication or infection. The thermally inactivated rotavirus is antigenic and retains a substantially intact rotavirus particle structure. Vaccine compositions and methods of vaccinating a subject against rotavirus are provided which include generation and use of thermally inactivated rotavirus.
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