Targeted human-interferon fusion proteins

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United States of America Patent

PATENT NO 10034919
SERIAL NO

15717205

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Abstract

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This disclosure relates to a modified α-helical bundle cytokine, with reduced activity via an α-helical bundle cytokine receptor, wherein the α-helical bundle cytokine is specifically delivered to target cells. Preferably, the α-helical bundle cytokine is a mutant, more preferably it is a mutant interferon, with low affinity to the interferon receptor, wherein the mutant interferon is specifically delivered to target cells. The targeting is realized by fusion of the modified α-helical bundle cytokine to a targeting moiety, preferably an antibody. This disclosure relates further to the use of such targeted modified α-helical bundle cytokine to treat diseases. A preferred embodiment is the use of a targeted mutant interferon, to treat diseases, preferably viral diseases and tumors.

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Patent Owner(s)

Patent OwnerAddress
UNIVERSITEIT GENTSINT-PIETERSNIEUWSTRAAT 25 GENT 9000
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE3 RUE MICHEL ANGE PARIS 75016
VIB VZWRIJVISSCHESTRAAT 120 9052 GENT BELGIUM
UNIVERSITE MONTPELLIER 2PLACE EUGENE BATAILLON 34000 MONTPELLIER
UNIVERSITAT OSNABRUCK49074 OSNABRÜCK
CENTRE HOSPITALIER REGIONAL UNIVERSITAIRE DE MONTPELLIER191 AVENUE DU DOYEN GASTON GIRAUD MONTPELLIER F-34295

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Cartron, Guillaume Combaillaux, FR 12 76
Paul, Franciane Montpellier, FR 13 124
Piehler, Jacob Osnabrück, DE 7 72
Tavernier, Jan Balegem, BE 92 456
Uzé, Gilles Montpellier, FR 6 64

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